i`D`Dp @@@ @@@@4=SDPD EN DB D     & . 67aFXV _try Week: 199303 RefMgr field[1]: Journal RefMgr field[8]: Not in File RefMgr field[26]: 0035-8835oxicity was enhanced following cryosurgery of normal liver and liver tumouro<5DB - MEDLINE UI - 93059318 IN - Department of Surgery, Royal Hallamshire Hospital, Sheffield JC - j3k Journal Subset AIM Journals CP - Scotland PT - Journal Article LG - English EM - 199212 Revised: 20001218. Entry Week: 199212 RefMgr field[1]: Journal RefMgr field[8]: Not in File RefMgr field[26]: 0141-2760lV ܐe@ݐܐ~,~,W_U̶< _dH< W_ '  ̶U  v as concurrent embolization, may be important to optimize the therapeutic effect of this device tractNotesURLAuthor AddressNewspaper ArticleYearzatPURPOSE: The LeVeen radiofrequency (RF) probe uses roll-off of electrical impedance as the endpoint for RF cautery of hepatic tumors. The purpose of this study is to determine the relation of roll-off to local control of hepatic tumors. MATERIALS AND METHOG Arkin1994Bastacky1995 Berger19966 Brown1998 Cao2000 Cao2002 Cheng1998 Chung1998 D2001 DM20011 Duerk1998 EJ2000 EJ2000 Emery1990 Fleischman1995 FT20011 Fujita1998: H1997H2000 H2000 H2001 Haemmerich2002 Holmes1994: Hunt19969 J-Z1997 J-Z2000 J-Z2000 J-Z2001 JA20000 Jain1999 JG19977 JG20000 JG20000 JG20011 Jr.2002 Kolios1996 Lee1995 Lewin1998 Mahvi2002 Mirotznik1995 Panescu1995 Poledna1996 S1997S2000 S2000 S2001 S2001 Schuele1998 Sekins1990 Sherar1996 Shvartsman1998 ST2001 Staelin2002 Swanson1995 Tsai2000s Tsai2002h Tungjitkusolmun2000Tungjitkusolmun2002 V2000  Vorperian2000 Vorperian2002 VR20000 VR20011 Webster1995 Webster2000 Webster2002 Whayne19955 Will2000 Wolf1999  Woo2000 Xu19949 h petacit muro,si cnulidgn1 0ehapotam sna d01m tesaates,sw re ertaeet.dL seoisnr naeg drfmo1 4.c mot6 0.c mnid aiemet;r1 35(%7 )ewers amllret ah n.3 0mc .aEhcl seoi naw sbaalet diwhtu eso fht eeLeVne1 -5aggu eFRn eeld ecaocdrni gott ehm nafucauter'r srptocolo .iFevp taeitn snuedwrne thcmeeobmlozitaoi nht ead yebofer .aPitnestw re eofllwodeu piwhtc nortsa-tneahcndec moupet dotomrgpayho ramngtecir senonaeci amiggna t 1omtn hna dvere y 3omtnsht eherfaet.rR SELUST :mAno ght e02l seoisn ,orllo- Authors<Journals Keywords U                               0< < Arkin, H. Bastacky, J. Berger, W. Brown, R.W. Cao, H. Cheng, Y.C. Chung, Y.C. D, Haemmerich DM, Mahvi Duerk, J.L. EJ, Woo Emery, A.F.Fleischman, S.D. FT, Lee Fujita, H. H, Cao Haemmerich, DHaemmerich, D. Holmes, K.R. Hunt, J. W. J-Z, Tsai JA, Will Jain, M.K. JG, WebsterJr., F. T. Lee Kolios, M. C. Lee, C.Y. Lehmann, J.F. Lewin, J.S. Mahvi, D. M.Mirotznik, M.S. Ozkan, OR Panescu, D. Poledna, J.S, Tungjitkusolmun Schuele, D.E. Sekins, K.M. Sherar, M. D.Shvartsman, S. ST, StaelinStaelin, S. T. Staelin, ST Swanson, D.K. Tsai, J-Z Tsai, J.-Z. Tsai, J.Z.Tungjitkusolmun, STungjitkusolmun, S. V, VorperianVorperian, V. R.Vorperian, V.R. VR, Voperian VR, Vorperian Webster, J.G. Webster, JG Whayne, J.G. Will, J.A. Wolf, P.D. Woo, E.J. Xu, L.X.   CryobiologyGen.Physiol Biophys.IEEE Trans. Biomed. Eng.0+IEEE Transactions on Biomedical EngineeringJ.Magn Reson.Imaging Med Phys  U0,*Body Temperature Regulation/ph [Physiology],'*Catheter Ablation/is [Instrumentation]83*Catheter Ablation/sn [Statistics & Numerical Data]*Cryopreservation *Electrodes *Freezing *Heart Ventricle/su [Surgery]("*Hyperthermia,Induced/mt [Methods]hys*Lung *Mathematics*Models,Biologicalced *Radio Waves *Temperature*Ultrasonic TherapyAbdominal NeoplasmsesAir Algorithms analysis AnimalArrhythmia/th [Therapy] BiophysicsbloodBlood Flow VelocityBlood PhysiologyaBlood/ph [Physiology] Body Temperature Regulation,&Body Temperature Regulation/physiology$ Body Temperature/ph [Physiology]s40Cardiac Surgical Procedures/is [Instrumentation]@Tungjitkusolmun S Woo EJ Cao H Tsai J-Z Vorperian V Webster JG 2000 2000analysis Electrodes:<5RefMgr field[1]: Journal RefMgr field[8]: Not in Filed2+IEEE Transactions on Biomedical Engineeringi47Goal: uniform current density. Current density is higher at junction between insulator and probe. Used FEM to model new electrode shapes to make current density more uniform. 583ZTThree-dimensional finite element analysis for radio-frequency hepatic tumor ablationf`Tungjitkusolmun S Staelin ST Haemmerich D Tsai J-Z Cao H Vorperian VR Lee FT Mahvi DM Webster JG 2001 2001analysisD>RefMgr field[1]: Unpublished Work RefMgr field[8]: Not in File82Submitted IEEE Trans Biomed Eng 2000 FEM of RITA model 30 electrode. 3D FEM shows mushroom shaped lesion at 8 min, Temp control 90 C. Lesion hot spots and total lesion volume change with presence of blood vessels at 10 and 1mm distance. 2D FEM with bifurcated blood vessel shows even more uneven lesion. 581<6How to perform finite element modeling for RF ablationTungjitkusolmun S 2001 2001D>RefMgr field[1]: Unpublished Work RefMgr field[8]: Not in File0*Tutorial on use of PATRAN to build models. @@     wurnal ArticleiUltrasound Med Biolt Antineoplastic Agents/pharmacology *Apoptosis Cell Count Cell Survival Cisplatin/pharmacology Comparative Study DNA Damage/drug effects DNA, Neoplasm/*drug effects Human Leukemia, Monocytic, Acute/*pathology/*ultrasonography Microscopy Support, Non-U.S. Gov't Tumor Cells, Culturedi Sekins,K.M. Emery,A.F. 1990,%Thermal Science for Physical Medicinev  Lehmann,J.F. Therapeutic Heat and Cold  Baltimore, MDa Williams & Wilkins744o4.Chart of thermal properties of various tissuesyTungjitkusolmun, S. S. T. Staelin D. Haemmerich J.-Z. Tsai H. Cao J.G. Webster F. T. Lee Jr. D. M. Mahvi V. R. Vorperian\ 2002ZTThree-dimensional finite element analyses for radio-frequency hepatic tumor ablationIEEE Trans. Biomed. Eng.49 3-9f 531,A new catheter design using needle electrode for subendocardial RF ablation of ventricular muscles: finite element analysis and in vitro experimentsXRWoo,E.J. Tungjitkusolmun,S. Cao,H. Tsai,J.Z. Webster,J.G. Vorperian,V.R. Will,J.A. 2000 1/2000*Catheter Ablation/is [Instrumentation] *Electrodes *Heart Ventricle/su [Surgery] analysis Animal Cattle Electrodes Equipment Design In Vitro Models,Cardiovascular Support,Non-U.S.Gov't Support,U.S.Gov't,P.H.S. Temperature United States 23-3102+IEEE Transactions on Biomedical Engineering471XRFEM of needle electrode to produce wider lesions. Compared to ex vivo bovine heartRadio-frequency (RF) cardiac ablation has been very successful for treating arrhythmias related with atrioventricular junction and accessory pathways with successful cure rates of more than 90%. Even though ventricular tachycardia (VT) is a more serious problem, it is known to be rather difficult to cure VT using RF ablation. In order to apply RF ablation to VT, we usually need to create a deeper and wider lesion. Conventional RF ablation electrodes often fail to produce such a lesion. We propose a catheter-electrode design including one or more needle electrodes with a diameter of 0.5-1.0 mm and length of 2.0-10 mm to create a lesion large enough to treat VT. One temperature sensor could be placed at the middle of the needle electrode for temperature-controlled RF ablation. From finite element analyses and in vitro experiments, we found that the depth of a lesion is 1-2 mm deeper than the insertion depth of the needle and the width increases as we increase the diameter of the needle and the time duration. We showed that a single needle electrode can produce a lesion with about 10-mm width and any required depth. If a wider lesion is required, more than one needle with suggested structures can be used. Or, repeated RF ablations around a certain area using one needle could produce a cluster of lesions. In some cases, a catheter with both conventional electrode and needle electrode at its tip may be beneficial to take advantage of both types of electrodeDB - MEDLINE UI - 20111754 IN - School of Electronics and Information, Kyung Hee University, Yongin, Kyongki-do, Korea JC - gfx, GFX, GFX, 0012737 Journal Subset Index Medicus CP - United States PT - Journal Article LG - English NO - HL56143 (NHLBI) EM - 20000208 Revised: 20001218. Entry Week: 20000208 RefMgr field[1]: Journal RefMgr field[8]: Not in File RefMgr field[26]: 0018-9294found that the depth of a lesion is 1-2 mm deeper than the insertion depth of the needle and the width increases as we increase the diameter of the needle and the time duration. We showed that a single needle electrode can produce a lesion with about 10-mm width and any required depth. If a wider lesion is required, more than one needle with suggested structures can be used. Or, repeated RF ablations around a certain area using one needle could produce a cluster of lesions. In some cases, a catheter with both conventional electrode and needle electrode at its tip may be beneficial to take advantage of both types of electrodeDB - MEDLINE UI - 20111754 IN - School of Electronics and Information, Kyung Hee University, Yongin, Kyongki-do, Korea JC - gfx, GFX, GFX, 0012737 Journal Subset Index Medicus CP - United States PT - Journal Article LG - English NO - HL56143 (NHLBI) EM - 20000208 Revised: 20001218. Entry Week: 20000208 RefMgr field[1]: Journal RefMgr field[8]: Not in File RefMgr field[26]: 0018-9294t\8839425g237i 1996 Jul882Blood flow cooling and ultrasonic lesion formation1287-98aThis article examines lesion formation using focused ultrasound and demonstrates how blood flow may affect lesion dimensions using a theoretical model. The effects of blood flow on temperature distributions during ultrasonic lesioning are examined for both regional cooling by the microvasculature and localized cooling due to thermally significant vessels. Regional cooling was critically assessed using two models: the Pennes bioheat transfer equation and the scalar effective thermal conductivity equation. Localized cooling was modeled by adding an advective term in the heat diffusion equation in regions enclosed by thermally significant vessels. A finite difference approach was used to solve the basic equations of heat transfer in perfused tissues in cylindrical coordinates. The extent of the lesioned tissue was determined by the accumulated thermal dose at each location. The size of the lesion was then calculated from the boundaries of the thermal isodose curves generated by the simulations. The results were compared to published in vivo lesion data in rat liver. It was shown that even for short ultrasound exposure times (approximately 8 s), blood flow may play an important role in the thermal dose distribution.'XRDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada..'Kolios, M. C. Sherar, M. D. Hunt, J. W. 0094-2405 Journal ArticleMed PhysAlgorithms Animal Biophysics Body Temperature Regulation/physiology Heat/therapeutic use Human Liver/blood supply/surgery Models, Biological Rats Regional Blood Flow/physiology Support, Non-U.S. Gov't Temperature *Ultrasonic Therapyjdhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8839425 424LFComparative mathematical analyses of freezing in lung and solid tissueLee,C.Y. Bastacky,J. 1995 8/1995RK*Cryopreservation *Freezing *Lung *Mathematics Air Animal Comparative Study Cryosurgery Freezing Frozen Sections Heat Liver/ah [Anatomy & Histology] Lung Lung/ah [Anatomy & Histology] Lung/su [Surgery] Organ Specificity Rats Support,Non-U.S.Gov't Support,U.S.Gov't,Non-P.H.S. Support,U.S.Gov't,P.H.S. United States Cryopreservationl299-305o Cryobiologyo324iIn contrast to most organs of the body, the lung is composed 80% of air and 20% of tissue. Because freezing of the lung is fundamental to cryomicroscopy, cryopreservation, and cryosurgery, mathematical analyses of freezing in lung and solid tissue were performed to determine differences in freezing behavior resulting from differences in tissue composition. A comparison of the cooling rates of these tissues is presented. At the microscopic level ultrarapid solidification is more rapid in the subpleural region of the lung than in the same region of solid tissue. In this region, the air insulates the lung tissue and prevents transfer of heat from surrounding regions. Cooling rates on the order of 10(6) K/s can be achieved in the pleura and outermost alveolar wall because their aggregate thickness is less than 5 microns in the rat. At the macroscopic level and after steady-state freezing has occurred, one-dimensional analyses show that freezing front propagation in the lung and solid tissue differs by less than 10%. This occurs even though the lung is less conductive than solid tissue; however, by having less heat storage capacity, the thermal diffusive property of lung is similar to that of solid tissueDB - MEDLINE UI - 95385349 IN - Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA JC - dt3, DT3, DT3, 0006252 Journal Subset AIM Journals CP - United States PT - Journal Article LG - English NO - HL45021 (NHLBI), HL52161 (NHLBI) EM - 199510 Revised: 20001218. Entry Week: 199510 RefMgr field[1]: Journal RefMgr field[8]: Not in File RefMgr field[26]: 0011-2240